Dr. Sahadev A. Shankarappa


Dr. Sahadev is a neuroscientist by training, specializing in neurobiology, neurophysiology, and drug delivery research. With postdoctoral training in the laboratories of Professors Robert Langer at MIT and Daniel Kohane at Boston Children’s Hospital, Harvard Medical School, his research focuses on understanding the impact of neural inputs on complex cellular systems with applications in tissue engineering and chronic lifestyle disorders. His lab explores how neural inputs, both secreted and electrical, modulate non-neuronal cell functions. Results from these studies aim to be translated into human studies for tissue engineering and disease-specific applications. Sahadev holds a Ph.D. in Neurosciences from Loyola University Chicago, an MPH from the University of North Carolina at Chapel Hill, and an M.B.B.S. from Bangalore University. A recipient of the Ramalingaswami reentry fellowship from the Department of Biotechnology, Government of India, Sahadev is not only passionate about neuroscience, but also practices meditation and enjoys long-distance running.


  • MBBS

    Kempegowda Institute of Medical Sciences, Bangalore, India

  • MPH

    University of North Carolina at Chapel Hill, NC, USA

  • PhD, Neuroscience

    Loyola University Chicago, Illinois, USA


Total Years of Experience: 14

Academic Experience: 14 years

  • Neural drug delivery
  • Nerve electrode systems
  • Neural controls in tissue regeneration

International Journal Papers

  • Antony A, Raju G, Job A, Joshi M, Shankarappa SA, Penetration of Topically Applied Polymeric Nanoparticles across the Epidermis of Thick skin from Rat,Biomedical Physics & Engineering Express, 2024
  • Madhusudanan P, Jerard C, Raju G, Katiyar N, Shankarappa SA, Nerve terminals in the tumor microenvironment as targets for local infiltration analgesia. Neuroscience Research, 2023
  • Jerard C, Madhusudanan P, Swamy A, Ravikumar K, Shankarappa SA, Secretome mediated interactions between sensory neurons and breast cancer cells. International Journal of Cancer, 2023
  • Varier P, Raju G, Madhusudanan P, Jerard C and Shankarappa SA, A Brief Review of In Vitro Models for Injury and Regeneration in the Peripheral Nervous System. Int. J. Mol. Sci. 2022; 23, 816.
  • Katiyar N, Raju G, Madhusudanan P, Gopalakrishnan VP, Shankarappa SA, Neuronal delivery of nanoparticles via nerve fibres in the skin. Scientific Reports, 2021;11:2566
  • Shiva Kumar B.S, Gopalakrishnan VP, Raju G, Mathew SE, Katiyar N, Menon D, Shankarappa SA, Anisotropic microparticles for differential drug release in nerve block anesthesia. RSC Advances, 2021; 11, 4623 – 4630
  • Madhusudanan P, Jerard C, Katiyar N, Raju G, Shankarappa SA, Effect of gold nanoparticle treated dorsal root ganglion cells on peripheral neurite differentiation. Toxicology in Vitro, 2021; 74, 105175
  • Gopalakrishnan VP, Mohanan A, Shiva Kumar B S, Madhusudanan P, Raju G, Menon D, Shankarappa SA, Electrical stimulation of co-woven nerve conduit for peripheral neurite differentiation. Biomed Mater, 2020; 15, 065015
  • Mathew SE, Madhusudanan P, Shankarappa SA, Effect of peritumoral bupivacaine on primary and distal hyperalgesia in cancer-induced bone pain. Journal of Pain Research, 2020; 17, 162, 20190505 
  • Madhusudanan P, Raju G and Shankarappa SA, Hydrogel systems and their role in neural tissue engineering. J R Soc Interface, 2020; 17, 20190505.
  • Dhwani NV, Raju G, Mathew SE, Baranwal G, Shivaram SB, Katiyar N, Pramanik N, Jhunjhunwala S, Shilpashree, H.B., Nagegowda DA, Kumar R, Shasany AK, Biswas R, Shankarappa SA, Antibacterial efficacy of Jackfruit rag extract against clinically important pathogens and validation of its antimicrobial activity in Shigella dysenteriae infected Drosophila melanogaster infection model. Indian J Exp Biol, 2020
  • Binoy A, Nedungadi D, Katiyar N, Bose C, Shankarappa SA, Nair BG, Mishra N, Plumbagin induces paraptosis in cancer cells by disrupting the sulfhydryl homeostasis and proteasomal function. Chemico-Biological Interactions, 2019; 310, 108733 – 13 
  • Raju G, Katiyar N, Vadukumpully S, Shankarappa SA. Penetration of gold nanoparticles across the stratum corneum layer of thick-Skin. J Dermatol Sci, 2018; 89(2), 146 – 154
  • Gopalakrishnan A, Shankarappa SA, Rajanikant GK. Hydrogel Scaffolds: Towards Restitution of Ischemic Stroke-Injured Brain. Transl Stroke Res, 2018;120(A), 439 – 18 
  • Ashok A, Mathew SE, Shivaram SB, Shankarappa SA, Nair SV, Shanmugam M. Cost Effective Natural Photo-sensitizer from Upcycled Jackfruit Rags for Dye Sensitized Solar Cells. Journal of Science: Advanced Materials and Devices, 2018;1 – 25
  • Mohandas A, Sun W, Nimal TR, Shankarappa SA, Hwang NS, Jayakumar R. Injectable chitosan-fibrin/nanocurcumin composite hydrogel for the enhancement of angiogenesis. Research on Chemical Intermediates, 2018; 1 – 15 
  • Madhusudanan P, Reade S, Shankarappa SA, Neuroglia as targets for drug delivery systems: A Review. Nanomedicine, 2017; 13(2), 667 – 679
  • Baranwal G, Mohammad M, Jarneborn A, Shankarappa SA. et al. Impact of cell wall peptidoglycan O‑acetylation on the pathogenesis of Staphylococcus aureus in septic arthritis. Int J Med Microbiol, 2017; 307(7), 388 – 397
  • Padmakumar S, John Joseph, Madhuri Nepalli Harsha, Mathew S, Nair SV, Shankarappa SA* and Menon D, Electrospun polymeric yarns in core-sheath architecture as drug eluting sutures, ACS Appl Mater Interfaces, 2016; 8 (11), 6925 – 6934 (* shared corresponding authorship)
  • Rwei AY, Lee JJ , Zhan C, Qian Liu , Meryem T Ok , Shankarappa SA , Langer R, Kohane DS, Repeatable and adjustable on-demand sciatic nerve block with photo-triggerable liposomes. Proc Natl Acad Sci USA, 2015; 112 (51), 15719 – 15724
  • Mohandas A, Nimal T.R, Das V, Shankarappa SA, Biswas R, Jayakumar R, Drug loaded bi-layered sponge for wound management in hyperfibrinolytic conditions. J. Mater. Chem. B, 2015; 3 (28), 5795 – 5805
  • Calik, MW; Shankarappa, SA; Langert, KA, Stubbs E.B,Jr., Forced-Exercise preconditioning attenuates experimental autoimmune neuritis by altering Th1 lymphocyte composition and egress. ASN Neuro, 2015; 7 (4), 1 – 11
  • Shankarappa SA, Koyakutty M, Shantikumar V Nair, Efficacy versus Toxicity — The Yin and Yang in translating nanomedicines. Nanomaterials and Nanotechnology, 2014; 4(23), 1
  • McAlvin B, Padera R, Shankarappa SA, Reznor G, Kwon AH, Chiang HH, Yang J, Kohane DS, Multivesicular liposomal bupivacaine at the sciatic nerve. Biomaterials, 2014; 35(15), 4557 – 4564
  • Timko BP, Arruebo M, Shankarappa SA, McAlvin B, Okonkwo OS, Mizrahi B, Stefanescue, CF, Gomez L, Zhu J, Zhu A, Santamaria J, Langer R, Kohane DS, Near-infrared-actuated devices for remotely controlled drug delivery. Proc Natl Acad Sci USA, 2014; 111(4), 1349 – 1354
  • Tian B, Shankarappa SA, Chiang H, Tong R, Monteiro I, Langer R, Kohane DS, Biodegradable mesostructured polymer membranes. Nano Lett, 2013; 13(9), 4410 – 4415
  • McAlvin B, Reznor G, Shankarappa SA, Stefanescu C, Kohane DS, Local toxicity from local anesthetic polymeric microparticles. Anesthesia and Analgesia, 2013; 116(4), 794 – 803
  • Mizrahi B, Shankarappa SA, Hickey J, Dolhman J, Timko BP, Whitehead KA, Lee J,-J, Langer R, Anderson DG, Kohane DS, A stiff injectable biodegradable elastomer. Adv Funct Mater, 2013; 25; 23(12), 1527 – 1533
  • Jung-Jae Lee, Jeong KJ, Hashimoto M, Kwon AH, Rwei A, Shankarappa SA, Tsui JH, and Kohane DS, Synthetic ligand-coated magnetic nanoparticles for microfluidic bacterial separation from blood. Nano lett, 2013; 14(1), 1 – 5
  • Liqiang Wang, Shankarappa SA* (*co- first author), Tong R, Ciolino JB, Tsui JH, Chiang HH, Kohane DS, Topical drug formulations for prolonged corneal anesthesia. Cornea, 2013; 32(7), 1040 – 1045
  • Shankarappa SA and Kohane DS, Can nerve blockade be used to manage neuropathic pain? Pain management, 2013; 3(2), 91 – 93 (invited editorial)
  • Shankarappa SA, Tsui JH, Kim K, Reznor G, Dolhman J, Langer R, Kohane DS, Prolonged nerve blockade delays the onset of neuropathic pain. Proc Natl Acad Sci USA, 2012; 109 (43), 17555 – 17560
  • Shankarappa SA, Sagie I, Tsui JH, Chiang H, Stefanescu C, Zurakowski D, Kohane DS, Duration and local toxicity of sciatic nerve blockade with co-injected site 1 sodium channel blockers and quaternary lidocaine derivatives. Reg Anesth Pain Med, 2012; 37(5), 483 – 489
  • Weldon CB, Tsui JT, Shankarappa SA, Nguyen VyT, Minglin Ma, Anderson DG, Kohane DS, Electrospun Drug-Eluting Sutures for Local Anesthesia. J Control Release, 2012; 17;161(3), 903 – 909
  • Calik MW, Shankarappa SA, Stubbs EB, Jr. Forced-exercise attenuates experimental autoimmune neuritis. Neurochem Int, 2012; 61,141−145
  • Shankarappa SA, Piedras-Renteria ES, Stubbs EB, Jr. Forced-exercise alleviates neuropathic pain in experimental diabetes: Effects on voltage-activated calcium channels. J Neurochem, 2011;118(2), 224 – 36


  • Formulations and Methods for Delaying Onset of Chronic Neuropathic Pain Sahadev Shankarappa and Daniel S Kohane, U.S. Patent No. 9,408,846 B2

  • Ramalingaswami fellow, DBT, India
  • Arthur J Schmitt Fellowship, Chicago

  • Society for Neurochemistry, Indian Chapter


  • Society for Neuroscience, USA


  • Indian Society of Nanomedicine


  • American chemical society


  • Society for biomaterials and artificial organs