Dr. Saraswathy G R

• Pharmaceutical care
• Drug Repurposing
• Systematic Review and Metaanalysis
• Computational Biology
• Her research interests are broad and encompass areas such as Pharmacology, Toxicology, and Pharmacotherapeutics, with a particular focus on clinical research in cardiovascular, neuro-psychiatric, gastrointestinal, and endocrine disorders. Currently, Dr. Saraswathy is dedicated to drug repurposing research, especially in the context of neurodegenerative diseases like Alzheimer’s and Parkinson’s disease. She has published over 50 research articles in renowned indexed journals with a cumulative Impact factor around 100.

• “Trailblazing Contemporary Frameworks for Drug Repurposing: A Saga on Drugs’ Expedition to Disinter the Veiled Destiny”. In: Rajput, V.S., Runthala, A. (eds) Drugs and a Methodological Compendium . Springer, Singapore. https://doi.org/10.1007/978-981-19-7952-1_9
• "Unveiling potential anticancer drugs through in silico drug repurposing approaches" of an Elsevier indexed book on "Drug Repurposing in Cancer Therapy" - 2020

• Recipient of International travel grant for participating and presenting research work on "Drug Utilisation Evaluation of Proton Pump Inhibitors in Gastroenterology" at 'International Society for Pharmacoeconomics and Outcomes Research Conference', Tokyo, Japan, during 8 – 11 September 2018.
• Recipient of scholarship for participating and presenting research work on "Drug Utilisation Evaluation of Anticoagulants in Patients with Atrial Fibrillation" at the 'Asian Conference on Pharmacoepidemiology' held at Queensland University, Brisbane, Australia, during 29 — 31 October 2017.
• Awarded Best Outgoing student award with first prize from KM College of Pharmacy, Madurai, affiliated to The Tamil Nadu Dr.MGR Medical University, Chennai during 2006.
• Recipient of Scholarship for M.Pharm., an academic project from The Tamil Nadu Pharmaceutical Sciences Welfare Trust, Chennai, India during 2003.

Cumulative Impact factor: 100

• Vastrad, S. J., Saraswathy, G. R., Dasari, J. B., Nair, G., Madarakhandi, A., Augustine, D., & Sowmya, S. V. (2025). A comprehensive transcriptome based meta-analysis to unveil the aggression nexus of oral squamous cell carcinoma. Biochemistry and Biophysics Reports, 42, 102001. https://doi.org/10.1016/j.bbrep.2025.102001
• Nair, G., Saraswathy, G.R., Aranjani, J.M. et al. (2025). Unraveling a novel therapeutic facet of Etravirine to confront Hepatocellular Carcinoma via disruption of cell cycle. Scientific Reports 15, 4979. https://doi.org/10.1038/s41598-025-87676-3
• Nair, G., Saraswathy, G. R., Gayam, P. K. R., Aranjani, J. M., Krishna Murthy, T. P., & Subeesh, V. (2024). Trailblazing real-world-data to confront hepatocellular carcinoma – disinterring repurposable drugs by amalgamating avant-garde stratagems. Journal of Biomolecular Structure and Dynamics, 1–15.
• Nair, G., Saraswathy, G. R., & Mathew, J. (2024, November). Pharmacovigilance Analysis of Immune-Related Adverse Effects to Uncover Repurposable Drugs for Hepatocellular Carcinoma. In Pharmacoepidemiology and Drug Safety 33, pp. 243–243. 111 River St, Hoboken, NJ, USA: Wiley.
• Satish K.S., Saraswathy G.R., Ritesh G., et al. (2024). Exploring cutting-edge strategies for drug repurposing in female cancers – An insight into the tools of the trade. Progress in Molecular Biology and Translational Science, 207:355–415. DOI: 10.1016/bs.pmbts.2024.05.002. PMID: 38942544.
• Satish KS, Saravanan KS, Augustine D, Saraswathy GR, V SS, Khan SS, H VC, Chakraborty S, Dsouza PL, N KH, Halawani IF, Alzahrani FM, Alzahrani KJ and Patil S (2024) Leveraging technology-driven strategies to untangle omics big data: circumventing roadblocks in clinical facets of oral cancer. Front. Oncol. 3;13:1183766
• Vastrad SJ, Ritesh G, V SS, Saraswathy GR, Augustine D, Alzahrani KJ, Alzahrani FM, Halawani IF, Ashi H, Alshahrani M, Hassan RN, Baeshen HA, Saravanan KS, Satish KS, Vutukuru P and Patil S (2023) Panoramic view of key cross-talks underpinning the oral squamous cell carcinoma stemness - unearthing the future opportunities. Front. Oncol. 13:1247399.
• Hemasree, G.N.S., Satish, K.S., Saraswathy G.R., Burri, R.R. and Murthy, T.K., 2023. Exploration of interaction interface of TRKβ/BDNF through fingerprint analysis to disinter potential agonists. Molecular Diversity, pp.1-19.
• G N S Hema Sree Lakshmi Prasanna Marise, Saraswathy Ganesan Rajalekshmi, Raghunadha R Burri, TP Krishna Murthy. Articulating target-mining techniques to disinter Alzheimer's specific targets for drug repurposing. Computer Methods and Programs in Biomedicine. Volume 222, July 2022, 106931 (Impact factor- 7.027, Elsevier, Pubmed indexed).
• Gouri Nair, G. N. S. Hema Sree, Ganesan Rajalekshmi Saraswathy, V. Lakshmi Prasanna Marise, T. P. Krishna Murthy. (2021) Application of comprehensive bioinformatics approaches to reconnoiter crucial genes and pathways underpinning hepatocellular carcinoma: a drug repurposing endeavor. Med Oncol, 38(12), pp. 145. (Impact factor- 3.738), Springer, Pubmed indexed).
• Hema Sree, G.N.S., Saraswathy Ganesan Rajalekshmi, Raghunadha, R.Burri (2021) Revelation of Pivotal Genes Pertinent to Alzheimer’s Pathogenesis: A Methodical Evaluation of 32 GEO Datasets. J Mol Neurosci,19; pp. 1-20. (Impact factor- 2.866), Springer, Pubmed indexed).
• Hema Sree G N S, V Lakshmi Prasanna Marise, Kshreeraja S Satish, Abhijna Vithal Yergolkar, Mamatha Krishnamurthy, Saraswathy Ganesan Rajalekshmi, K Radhika, Raghunadha R Burri. Untangling huge literature to disinter genetic underpinnings of Alzheimer’s Disease: A Systematic review and Meta-analysis. Ageing Res Rev. 2021 Aug 6;101421. doi: 10.1016/j.arr.2021.101421. (Impact factor- 11.788, Elsevier, Pubmed indexed).
• Priyadharshini Ramakrishnan, T Pavan Kumar, G R Saraswathy, S Sujatha. In silico evaluation of drugs used in treatment of oral lichen planus. J Oral Pathol Med. 2020 Oct;49(9):926-932. (Impact factor- 3.539, Wiley Online Library, Pubmed indexed)
• Minnikanti Venkata Satya Sai, Viswam Subeesh, Hema Sree G N S, Ganeshan Rajalakshmi Saraswathy, Nair Gouri. Prediction of Potential Targets of an Emerging Zoonotic Paramyxovirus: An Integrated Bioinformatics Analysis. Current Pharmacogenomics and Personalized Medicine. 2021 (Bentham)
• Divyashri G ORCID, Krishna Murthy, Subramaniam Sundareshan, Pavan Kamath, Manikanta Murahari, Saraswathy GR, Bindu Sadanandan. In silico approach towards the identification of potential inhibitors from Curcuma amada Roxb against H. pylori: ADME screening and molecular docking studies. BioImpacts. 2020;11(2) Q1 Scopus indexed Impact factor- 3.783, Pubmed indexed.
• Viswam Subeesh, Eswaran Maheswari, Hemendra Singh, Ganesan Rajalekshmi Saraswathy, Neha Reddy & Pudi Chiranjeevi (2020) Early prediction of clinical response in first episode schizophrenia (FES) patients receiving olanzapine, International Journal of Psychiatry in Clinical Practice, DOI: 10.1080/13651501.2020.1757118. Impact factor- 1.8, Taylor and Francis.
• Hema Sree G N S, Saraswathy GR, Manikanta Murahari, R R Burri. Reappraisal of FDA approved drugs against Alzheimer’s disease based on differential gene expression and protein interact network analysis: An in silico approach. Journal of Biomolecular Structure and Dynamics 2019 Oct 14;1-18. doi: 10.1080/07391102.2019.1671231. (Impact Factor: 5.235. Taylor and Francis, Pubmed indexed).
• Halumatha Surendra ShreeShilpa, N. Naveen Kumar, Eswaran Maheswari, Harave Shanmugam Virupaksha, Viswam Subeesh, Ganesan Rajalekshmi Saraswathy, Radhika Kunnavil. Deprescribing of benzodiazepines and Z-drugs amongst the psychiatric patients of a tertiary care Hospital. Asian Journal of Psychiatry, Volume 44, August 2019, Pages 189-194. Impact Factor – 13.89, Pubmed and Scopus Indexed
• Kumari Sweta, Doorva Bhat, Ganesan Rajalekshmi Saraswathy, E. Maheswari. The Views of Indian Practitioners on Deprescribing. Journal of General Internal Medicine. 2019 Jun;34(6):828-830. Impact Factor – 6.43, Springer, Pubmed Indexed
• Hema Sree GNS, Saraswathy GR, Manikanta Murahari, Mamatha Krishnamurthy. An update on Drug Repurposing: Re-written saga of the drug's fate. Biomed Pharmacother. 2019; 110:700-716. Impact Factor – 7.419, Pubmed and Scopus Indexed
• Doorva Bhuvanendra Bhat, Ganesan Rajalekshmi Saraswathy, Kumari Sweta. Development and Validation of the Perceptions, Attitudes, and Challenges of Physicians Towards Deprescribing (PACPD-12) Questionnaire. Journal of American Medical Directors Association. Volume 19, Issue 12,2018 Page: 1135– 1136. Impact Factor – 7.802, Pubmed and Scopus Indexed
• Theivendren P, Kunjiappan S, Govindraj S, Chandrasekarn J, Pavadai P, Saraswathy GR, Murugan I. Graph Theoretical Analysis, Insilico Modelling and Formulation of Pyrimidine Nanoparticles as p38α MAP Kinases inhibitors: A Quantitative Proteomics Approach. Drug Res (Stuttg), 2019 Feb;69(2):100-110.– Pubmed and Scopus Indexed
• Tejaswi Gummadi, Virupaksha Shanmugam Harave, Lakshmi Narayan Aiyar, Saraswathy Ganesan Rajalekshmi, RadhikaKunnavil. Adverse drug reaction monitoring in a tertiary care psychiatry setting: a comparative study between inpatients and outpatients. Indian Journal of Psychological medicine 2017, Volume: 39, Issue: 3, Page: 306-311, 2017. Pubmed and Scopus Indexed
• A Lakshmi Narayan, HS Virupaksha, G Thejaswi, GR Saraswathy, V Madhavan, MuraliThyloth. A case report on varenicline induced delirium in an alcohol and nicotine dependent patient. Indian Journal of Psychological medicine, 2015,37(3):355-357. Pubmed and Scopus Indexed
• Maheswari E, Saraswathy GR, Santhrani T. Hepatoprotective and antioxidant activity of N-acetyl cysteine in carbamazepine administered rats. Indian Journal of Pharmacology, 2014; 46(2): 211-215. Impact Factor – 2.833, Pubmed and Scopus Indexed
• Christina AJ, Saraswathy GR, Robert SJ, Kothai R, Chidambaranathan N, Nalini G, Therasal RL. Inhibition of CCl4- induced liver fibrosis by Piper longumLinn?. Phytomedicine. 2006;13(3):196-198. Impact Factor – 6.656, Pubmed Indexed
• Benita Lisa Baji, Tasmiya K, Saraswathy GR, Ann Mary Swaroop, MaheswariEswaran, ViswamSubeesh. Current trends in the pharmacological treatment of diabetic complications in a tertiary care setting. J. Res. Pharm. Sci., 2019; 10(1), 140-145. Scopus Indexed
• Namrata Bajracharya, Ann Mary Swaroop, Saraswathy Ganesan Rajalekshmi, Subeesh K Viswam, Maheswari E.“Incidence of DrugInteractions among patients admitted to the Department of General Medicine in a Tertiary care hospital”. J Young Pharm, 2018; 10(4): 450-455. Scopus Indexed
• Viswam Subeesh, Eswaran Maheswari, Saraswathy GR, Minnikanti SS, Ann Mary S. A Comparative Study of Data Mining Algorithms used for Signal Detection in FDA AERS Database. Journal of Young Pharmacist. 2018; 10(4): 444-449. Scopus Indexed
• Jacquline Elza Johnson, Prathap Raja Varma MAN, Eswaran Maheswari, Saraswathy GR. Assessment of health and quality of life of children residing in selected shelter homes in Bangalore. Journal of Applied Pharmaceutical Science 2018; 8(04):084-089. Scopus Indexed
• Jinin S. Mathew, M. R. V. Nandini, G. R. Saraswathy, Viswam Subeesh, Eswaran Maheswari. Determinants of Gastroesophageal Reflux Disease (GERD) severity and Utilization of Proton Pump Inhibitors among GERD Patients: A Cross-Sectional Study. Journal of Applied Pharmaceutical Science Volume: 7, Issue: 11, November, 2017. Scopus Indexed
• Eswaran Maheswari, Lydia Abraham, Chinju Susan Chacko, Ganesan Rajalekshmi Saraswathy, ArunaChala Ramesh. Assessment of Pattern, Severity and Outcome of Poisoning in Emergency Care Unit. Journal of Applied Pharmaceutical Science. December, 2016; 6(12): 178-183. Scopus Indexed
• Saraswathy GR, Maheswari E, Santhrani, Anbu J. Reversal of phenytoin induced hepatotoxicity by alpha lipoic acid in rats. African Journal of Pharmacy and Pharmacology. 2015; 9(7): 198- 204. Scopus Indexed
• Saraswathy GR, Maheswari E, Santhrani T. Effect of Vitamin C supplementation on phenytoin induced behavioural abnormalities and regional lipid peroxidation in rats. IJPT. 2011; 3(2): 2248-2269. Scopus Indexed
• Santh Rani T, Saraswathy GR, Maheswari, E, Sunil Kumar N, Hazarathiah T, Sowmya, KR, Dwarakanadha Kumar P, Ramesh B. Inhibition of CCl4 – induced liver fibrosis by Trigonella foenumgraecum Linn. Natural Product Radiance. 2007; 6:1. Scopus Indexed
• Santhrani T, Latha P, Veena G, Madhavi M, Saraswathy GR and Maheswari E. Treatment of HIV- infected diabetic patients. Pharmacologyonline. 2010; 3: 61-75. Scopus Indexed
• Saraswathy GR, Maheswari E and Santhrani T. Effect of Vitamin C Supplementation on Phenytoin Induced Hepatotoxicity. Global Journal of Pharmacology. 2010;4(3):127-135. Scopus Indexed
• Maheswari E, Saraswathy GR, Santh Rani T, Narmada S. Comparative study on efficacy and toxicity of chemoradiotherapy and radiotherapy in head, neck and cervix cancer patients. Pharmacologyonline. 2009; 1: 688-704. Scopus Indexed
• AshokaBabu VL, Priyanka A, Saraswathy GR, Madhavan V. Evaluation of wound healing potential of aqueous and ethanolic extracts of RhyncosiaBeddomei Baker leaves in Wistar rats. World J Pharm Sci. 2015; 3(2): 251-257.
• Anbu J, Ramya Krishna PS, Ramya HS, Vineeth Reddy, Sathiya R and Saraswathy GR. Management of inflammatory bowel disease and experimental models established for evaluation- An update. World Journal of Pharmacy and Pharmaceutical Sciences. 2015; 4(5): 1065-1086.
• Maheswari E, Saraswathy GR, Santhranii T. Influence of Vitamin E on Hepatotoxicity and Oxidative Stress. International Journal of Research in Pharmacy and Biosciences. 2015; 2(3): 30-38.
• Maheswari E, Saraswathy GR, Santhranii T. Effect of Vitamin C on Behavioral Abnormalities and Regional Brain Lipid Peroxidation. International Journal Of Pharmaceutical And Chemical Sciences. 2015; 4(1): 132-146.
• Saraswathy GR, Sathiya R, Anbu J, Maheswari E. Antitussive Medicinal Herbs - An Update Review. International Journal of Pharmaceutical Sciences and Drug Research 2014; 6(1): 12-19.
• Saraswathy GR, Maheswari E, Santhrani T, Anbu J. N Acetyl Cysteine Alleviates Phenytoin Induced Behavioral Abnormalities in Rats. IJPSR, 2014; 5(8): 3279-3292.
• Santhrani T, Maheswari E, Saraswathy GR. Carbamazepine provoked hepatotoxicity: attenuation by vitamin C. OxidAntioxidMed Sci. 2013; 2(1): 37-43.
• Santhrani T, Maheswari E, Saraswathy GR. Amelioration of carbamazepine induced oxidative stress and hematotoxicity by vitamin C. Spatula DD. 2012; 2(3): 173-180.
• Suma BV, Natesh NN, Saraswathy GR, Madhavan V. Synthesis and pharmacological evaluation of some novel benzotriazoles derivatives containing pyrazolidinedione moieties. International Journal of Pharmacy & Therapeutics. 2012; 3(2):100-106.
• Santh Rani T, Deepti V, Sowjanya N, Maheswari E and Saraswathy GR. Study of the utilization pattern of antimicrobials in paediatric outpatients. J Pharm Res. 2007; 6(2): 104-107.
• Santh Rani T, Deepti V, Sowjanya N, Saraswathy GR and Maheswari E. Utilization of antimicrobials in inpatients in a referral hospital. The Antiseptic. 2007; 104(10):508-512.

Conference publications:

• Krishnan, A., Satish, K., & Saraswathy, G. R. (2025). 157P Target identification and exploring drug repurposing strategies for Merkel cell carcinoma. ESMO Open, 10, 104471. https://doi.org/10.1016/j.esmoop.2025.104471
• Abraham, T., Satish, K., & Saraswathy, G. R. (2025). 159P Proteasome inhibitors linked to Bowen's disease: Mechanistic insights from integrative bioinformatics guided disproportionality analysis of FAERS database. ESMO Open, 10, 104473. https://doi.org/10.1016/j.esmoop.2025.104473
• Bhargava, J., Satish, K., & Saraswathy, G. R. (2025). 9P Exploration of molecular targets and drug repurposing approaches for therapeutic advancement in primary central nervous system lymphoma. ESMO Open, 10, 104310. https://doi.org/10.1016/j.esmoop.2025.104310

• Membership as a life member in Association of Pharmaceutical Teachers of India (APTI). Membership number AP/LM-210.
• Indian Association of Colleges of Pharmacy.
• International Society of Pharmacoeconomics and Outcomes Research
• Association of Community Pharmacist of India.
• IACP Membership KALM 015