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Ramaiah University of Applied Sciences

Shailja Raje

Dr. Shailja Raje

Assistant Professor

Dr. Shailja Raje joined as an Assistant Professor in Department of Biotechnology, FLAHS, RUAS in November 2020. She earned her Ph.D degree in Molecular Biophysics from Indian Institute of Technology Roorkee in 2020. Before this she was in Indian Institute of Technology Roorkee for pursuing her M.Sc in Biotechnology. Her B.Sc. was from Patna Science College with specialization in Biotechnology.

Qualifications

  • Ug

    Patna Science College.

  • PG

    Indian Institute of Technology Roorkee.

  • PHD

    Indian Institute of Technology Roorkee.

Experience

Total Years of Experience: 3.5 Months

Training Experience

Surface Plasmon Resonance (SPR), Nuclear Magnetic Resonance (NMR).

  • G‑quadruplex DNA
  • Drug DNA interaction
  • Molecular Biophysics
  • Structural Biology

Ph.D. Dissertation:

  • Interaction of Anthracyclines with Human Telomeric G‑Quadruplex DNA.

National Conference Papers

Raje, S.

and Barthwal, R. (2016). Interaction of adriamycin with G‑quadruplex telomeric DNA sequence d-(TTGGGGT)4 by Nuclear Magnetic Resonance spectroscopy methods, Shailja Raje and Ritu Barthwal. Recent Advances in

  • Biomedical Research: Strategies and Innovation, AIIMS New Delhi, 26 – 27 May 2016.
  • Raje, S. and Barthwal, R. (2018). Interaction of Doxorubicin with G‑quadruplex DNA leads to stabilization: NMR study, Shailja Raje and Ritu Barthwal. National Magnetic Resonance Society of India, IISER Mohali, 16 – 19 February 2018.

International Conference Papers

  • Raje, S. and Barthwal, R. (2018). Interaction of doxorubicin with 22-mer G‑quadruplex sequence d-[AGGG(TTAGGG)3] from human telomeric DNA. International Conference on Frontiers at the-Chemistry Allied Science Interface, University of Rajasthan, Jaipur, 21 – 22 December 2018.

International Journal Papers

  • Raje, S. and Barthwal, R. (2019). Molecular recognition of 3+1 hybrid human telomeric G‑quadruplex DNA d-[AGGG(TTAGGG)3] by anticancer drugs epirubicin and adriamycin leads to thermal stabilization. International Journal of Biological Macromolecules, 139, 1272 – 1287.
  • Raje, S., Pandav, K. and Barthwal, R. (2019). Binding of anticancer drug adriamycin to parallel G‑quadruplex DNA [d-(TTAGGGT)]4 comprising human telomeric DNA leads to thermal stabilization: a multiple spectroscopy study. Journal of molecular recognition, e2815, doi​.org/​1​0​.​1​0​0​2​/​j​m​r​.2815.
  • Raje, S., Pandav, K. and Barthwal, R. (2019). Dual mode of binding of anti cancer drug epirubicin to G‑quadruplex [d-(TTAGGGT)]4 containing human telomeric DNA sequence induces thermal stabilization. Bioorganic & Medicinal Chemistry, 27, 115131.
  • Barthwal, R., Raje, S. and Pandav, K. (2019). Structural basis for stabilization of human telomeric G‑quadruplex [d-(TTAGGGT)]4 by anticancer drug adriamycin. Journal of Biomolecular Structure and Dynamics, 10.1080/07391102.2020.1730969.
  • Barthwal, R., Raje, S. and Pandav, K. (2020). Structural basis for stabilization of human telomeric G‑quadruplex [d-(TTAGGGT)]4 by anticancer drug epirubicin. Bioorganic&MedicinalChemistry,10.1016/j.bmc.2020.115761.

  • Received JRF and SRF (Research Fellowship) by MHRD from 2014 – 2019.
  • Qualified written round of JGEEBILS conducted by Tata Institute of Fundamental Research (TIFR) in 2014.
  • Recipient of Department of Biotechnology (DBT) scholarship from Government of India in M.Sc. (2012−2014).
  • Obtained All India Rank 22nd in Joint Admission for M.Sc. Exam (JAM) conducted by Indian Institute of Technology, Bombay in 2012.
  • Obtained All India Rank 129 in exam conducted by JNU for admission in M.Sc Biotechnology in 2012.
  • Qualified in the exam conducted by Indian Council of Agricultural Research (ICAR) in 2009).